Igf1-LR3 1mg

Description

IGF-1 LR3 is a synthetic, modified version of the natural human hormone IGF-1, with enhanced stability and a significantly longer half-life, promoting muscle growth and repair by activating IGF-1 receptors to stimulate cell proliferation, differentiation, and protein synthesis.

How it Works

IGF-1 LR3 interacts with the IGF-1 receptor, triggering pathways like PI3K/Akt and MAPK/ERK, which are crucial for cellular growth and differentiation.

Benefits

Anabolic Effects: Stimulates protein synthesis, leading to increased muscle mass and strength.

Enhanced Recovery: Promotes tissue repair and regeneration.

Metabolic Regulation: Influences glucose uptake and metabolic processes.

Key Modifications and Effects

N-terminal Extension: Has an additional 13 amino acids at its N-terminus.

Arginine Substitution: Contains an arginine instead of a glutamic acid at the third position.

Increased Half-Life: These modifications result in a longer half-life of approximately 20–30 hours, compared to the ~12–15 hours of native IGF-1.

Reduced IGFBP Binding: Its structure reduces binding to IGF binding proteins, allowing it to remain bioactive for longer.

Applications

Research: Used in experimental models to study peptide-mediated anabolic signaling.

Cell Culture: An effective supplement in cell culture for promoting cell proliferation, survival, and differentiation.

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