FOXO4-DRI 10mg

Description

FOXO4-DRI (D-Retro-Inverso) is a synthetic, senolytic peptide designed to combat aging and age-related decline by selectively inducing apoptosis (programmed cell death) in senescent “zombie” cells. By interrupting the FOXO4-p53 interaction, it forces these dysfunctional cells to die, showing potential to restore health span, improve liver/kidney function, and boost fitness in animal studies.

Key Aspects of FOXO4-DRI Peptide:

Mechanism of Action: Senescent cells, which accumulate with age and cause tissue inflammation, rely on a specific interaction between the FOXO4 protein and the p53 protein to avoid apoptosis. FOXO4-DRI binds to p53, releasing it from FOXO4, which triggers p53-mediated, caspase-dependent cell death in these cells while leaving healthy cells unharmed.

Design & Structure: It is a 43-amino acid peptide engineered as a “D-retro-inverso” variant, meaning it uses D-amino acids in reverse order to the natural L-form. This modification makes it highly resistant to enzymatic degradation, increasing its stability and effectiveness.

Research & Potential Benefits:

Anti-Aging: Preclinical studies, often in mice, have indicated potential in reversing signs of aging, such as hair loss, reduced fitness, and diminished kidney function.

Chemotherapy Support: It has shown promise in reducing the副作用 of chemotherapy, which can induce senescence in healthy tissues.

Specific Applications: Research has investigated its use in clearing senescent chondrocytes for cartilage repair and treating age-related testosterone decline in Leydig cells.

Availability: FOXO4-DRI is primarily a research chemical used in laboratory settings and is not approved for human consumption or therapeutic use. It is sometimes referred to as Proxofim in research contexts.

Disclaimer: FOXO4-DRI is an investigational compound for research use only, not a approved medicine.

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